High Molecular Weight Gingipains from <i>Porphyromonas gingivalis</i> Induce Cytokine Responses from Human Macrophage-Like Cells via a Nonproteolytic Mechanism

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High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism.

Periodontal disease is an oral inflammatory disease affecting the supporting structures of teeth. Porphyromonas gingivalis, a major pathogenic agent for the disease, expresses a number of virulence factors, including cysteine proteases called the gingipains. The arginine- and lysine-specific gingipains, HRgpA and Kgp, respectively, are expressed as high molecular weight forms containing both ca...

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ژورنال

عنوان ژورنال: Journal of Innate Immunity

سال: 2008

ISSN: 1662-811X,1662-8128

DOI: 10.1159/000181145